Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells
作者： Roberta Zaninetti , Alessandra Fornarelli , Monica Ciarletta , Dmitry Lim , Antonio Caldarelli
DOI: 10.1111/J.1471-4159.2010.07144.X
关键词:
摘要: J. Neurochem. (2011) 116, 606–615. Abstract Calcium is a universal signal, and its capacity to encode intracellular messages via spatial, temporal amplitude characteristics allows it participate in most cellular events. In specific context, calcium plays pivotal role migration, although has not been elucidated fully. By using immortalized gonadotropin-releasing hormone-secreting neurons (GN11), we have now investigated the of TRPV4, member vanilloid family Ca2+ channels, neuronal migration. Our results show that TRPV4 channels are present functional GN11 cells their localization polarized enriched lamellipodial structures. activation leads retraction lamellipodia decrease migratory behaviour; moreover migrate slower more random manner. We therefore provide evidence for new regulation hormone at leading edge cells.
core.ac.uk
sci-hub.se 参考文章(31)
Michael J. Berridge, The Versatility and Complexity of Calcium Signalling Novartis Foundation Symposia. ,vol. 239, pp. 52- 67 ,(2001) , 10.1002/0470846674.CH6
Juliet Lee, Akira Ishihara, Gerry Oxford, Barry Johnson, Ken Jacobson, Regulation of cell movement is mediated by stretch-activated calcium channels Nature. ,vol. 400, pp. 382- 386 ,(1999) , 10.1038/22578
Bernd Nilius, Grzegorz Owsianik, None, Channelopathies converge on TRPV4 Nature Genetics. ,vol. 42, pp. 98- 100 ,(2010) , 10.1038/NG0210-98
Chen-bing Guan, Hua-tai Xu, Ming Jin, Xiao-bing Yuan, Mu-ming Poo, Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by slit-2. Cell. ,vol. 129, pp. 385- 395 ,(2007) , 10.1016/J.CELL.2007.01.051
R. Zaninetti, S. Tacchi, J. Erriquez, C. Distasi, R. Maggi, A. Cariboni, F. Condorelli, P. L. Canonico, A. A. Genazzani, Calcineurin primes immature gonadotropin-releasing hormone-secreting neuroendocrine cells for migration. Molecular Endocrinology. ,vol. 22, pp. 729- 736 ,(2008) , 10.1210/ME.2007-0277
Matthew J Rock, Jean Prenen, Vincent A Funari, Tara L Funari, Barry Merriman, Stanley F Nelson, Ralph S Lachman, William R Wilcox, Soraya Reyno, Roberto Quadrelli, Alicia Vaglio, Grzegorz Owsianik, Annelies Janssens, Thomas Voets, Shiro Ikegawa, Toshiro Nagai, David L Rimoin, Bernd Nilius, Daniel H Cohn, Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nature Genetics. ,vol. 40, pp. 999- 1003 ,(2008) , 10.1038/NG.166
Hiroyuki Watanabe, Joris Vriens, Jean Prenen, Guy Droogmans, Thomas Voets, Bernd Nilius, Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels Nature. ,vol. 424, pp. 434- 438 ,(2003) , 10.1038/NATURE01807
Marco Mank, Dierk F. Reiff, Nicola Heim, Michael W. Friedrich, Alexander Borst, Oliver Griesbeck, A FRET-Based Calcium Biosensor with Fast Signal Kinetics and High Fluorescence Change Biophysical Journal. ,vol. 90, pp. 1790- 1796 ,(2006) , 10.1529/BIOPHYSJ.105.073536
Chandan Goswami, Julia Kuhn, Paul A. Heppenstall, Tim Hucho, Importance of Non-Selective Cation Channel TRPV4 Interaction with Cytoskeleton and Their Reciprocal Regulations in Cultured Cells PLOS ONE. ,vol. 5, ,(2010) , 10.1371/JOURNAL.PONE.0011654
Marlene Schwanzel-Fukuda, Donald W. Pfaff, Origin of luteinizing hormone-releasing hormone neurons. Nature. ,vol. 338, pp. 161- 164 ,(1989) , 10.1038/338161A0