Distance from Sub-Saharan Africa Predicts Mutational Load in Diverse Human Genomes

Brenna M. Henn, Laura R. Botigué, Carlos D. Bustamante, Andrew G. Clark, Simon Gravel, Estimating the mutation load in human genomes. Nature Reviews Genetics. ,vol. 16, pp. 333- 343 ,(2015) , 10.1038/NRG3931

Fernanda SG Kehdy, Mateus H Gouveia, Moara Machado, Wagner CS Magalhães, Andrea R Horimoto, Bernardo L Horta, Rennan G Moreira, Thiago P Leal, Marilia O Scliar, Giordano B Soares-Souza, Fernanda Rodrigues-Soares, Gilderlanio S Araújo, Roxana Zamudio, Hanaisa P Sant Anna, Hadassa C Santos, Nubia E Duarte, Rosemeire L Fiaccone, Camila A Figueiredo, Thiago M Silva, Gustavo NO Costa, Sandra Beleza, Douglas E Berg, Lilia Cabrera, Guilherme Debortoli, Denise Duarte, Silvia Ghirotto, Robert H Gilman, Vanessa F Gonçalves, Andrea R Marrero, Yara C Muniz, Hansi Weissensteiner, Meredith Yeager, Laura C Rodrigues, Mauricio L Barreto, M Fernanda Lima-Costa, Alexandre C Pereira, Maíra R Rodrigues, Eduardo Tarazona-Santos, Brazilian EPIGEN Project Consortium, None, Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations Proceedings of the National Academy of Sciences. ,vol. 112, pp. 8696- 8701 ,(2015) , 10.1073/PNAS.1504447112

Terumi Mukai, Sadao I Chigusa, L E Mettler, James F Crow, Mutation Rate and Dominance of Genes Affecting Viability in DROSOPHILA MELANOGASTER Genetics. ,vol. 72, pp. 335- 355 ,(1972) , 10.1093/GENETICS/72.2.335

Federico Manna, Guillaume Martin, Thomas Lenormand, Fitness Landscapes: An Alternative Theory for the Dominance of Mutation Genetics. ,vol. 189, pp. 923- 937 ,(2011) , 10.1534/GENETICS.111.132944

Holly K Tabor, Paul L Auer, Seema M Jamal, Jessica X Chong, Joon-Ho Yu, Adam S Gordon, Timothy A Graubert, Christopher J O’Donnell, Stephen S Rich, Deborah A Nickerson, Michael J Bamshad, None, Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results. American Journal of Human Genetics. ,vol. 95, pp. 183- 193 ,(2014) , 10.1016/J.AJHG.2014.07.006

Aneil F. Agrawal, Michael C. Whitlock, Inferences about the distribution of dominance drawn from yeast gene knockout data. Genetics. ,vol. 187, pp. 553- 566 ,(2011) , 10.1534/GENETICS.110.124560

Michael J. Bamshad, Joshua M. Akey, , , , Jacob A. Tennessen, Abigail W. Bigham, Timothy D. O’Connor, Wenqing Fu, Eimear E. Kenny, Simon Gravel, Sean McGee, Ron Do, Xiaoming Liu, Goo Jun, Hyun Min Kang, Daniel Jordan, Suzanne M. Leal, Stacey Gabriel, Mark J. Rieder, Goncalo Abecasis, David Altshuler, Deborah A. Nickerson, Eric Boerwinkle, Shamil Sunyaev, Carlos D. Bustamante, Evolution and functional impact of rare coding variation from deep sequencing of human exomes Science. ,vol. 337, pp. 64- 69 ,(2012) , 10.1126/SCIENCE.1219240

Ryan D Hernandez, Joanna L Kelley, Eyal Elyashiv, S Melton, Adam Auton, Gilean McVean, Guy Sella, Molly Przeworski, None, Classic Selective Sweeps Were Rare in Recent Human Evolution Science. ,vol. 331, pp. 920- 924 ,(2011) , 10.1126/SCIENCE.1198878

Yuval B Simons, Michael C Turchin, Jonathan K Pritchard, Guy Sella, The deleterious mutation load is insensitive to recent population history Nature Genetics. ,vol. 46, pp. 220- 224 ,(2014) , 10.1038/NG.2896

Laura B. Scheinfeldt, Sarah A. Tishkoff, Recent human adaptation: genomic approaches, interpretation and insights Nature Reviews Genetics. ,vol. 14, pp. 692- 702 ,(2013) , 10.1038/NRG3604