Isolation, structure and fatty acid synthesis inhibitory activities of platensimycin B1-B3 from Streptomyces platensis.

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Jun Wang, Srinivas Kodali, Sang Ho Lee, Andrew Galgoci, Ronald Painter, Karen Dorso, Fred Racine, Mary Motyl, Lorraine Hernandez, Elizabeth Tinney, Steven L. Colletti, Kithsiri Herath, Richard Cummings, Oscar Salazar, Ignacio González, Angela Basilio, Francisca Vicente, Olga Genilloud, Fernando Pelaez, Hiranthi Jayasuriya, Katherine Young, Doris F. Cully, Sheo B. Singh, Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 7612- 7616 ,(2007) , 10.1073/PNAS.0700746104

Hiranthi Jayasuriya, Kithsiri B. Herath, John G. Ondeyka, Deborah L. Zink, Bruce Burgess, Jun Wang, Sheo B. Singh, Structure of homoplatensimide A : a potential key biosynthetic intermediate of platensimycin isolated from Streptomyces platensis Tetrahedron Letters. ,vol. 49, pp. 3648- 3651 ,(2008) , 10.1016/J.TETLET.2008.03.155

Sheo B. Singh, Hiranthi Jayasuriya, John G. Ondeyka, Kithsiri B. Herath, Chaowei Zhang, Deborah L. Zink, Nancy N. Tsou, Richard G. Ball, Angela Basilio, Olga Genilloud, Maria Teresa Diez, Francisca Vicente, Fernando Pelaez, Katherine Young, Jun Wang, Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy. Journal of the American Chemical Society. ,vol. 128, pp. 11916- 11920 ,(2006) , 10.1021/JA062232P

Kithsiri B. Herath, Chaowei Zhang, Hiranthi Jayasuriya, John G. Ondeyka, Deborah L. Zink, Bruce Burgess, Jun Wang, Sheo B. Singh, Structure and Semisynthesis of Platensimide A, Produced byStreptomyces platensis Organic Letters. ,vol. 10, pp. 1699- 1702 ,(2008) , 10.1021/OL800251V

Hiranthi Jayasuriya, Kithsiri B. Herath, Chaowei Zhang, Deborah L. Zink, Angela Basilio, Olga Genilloud, Maria Teresa Diez, Francisca Vicente, Ignacio Gonzalez, Oscar Salazar, Fernando Pelaez, Richard Cummings, Sookhee Ha, Jun Wang, Sheo B. Singh, Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad‐Spectrum Antibiotic Activity Angewandte Chemie. ,vol. 46, pp. 4684- 4688 ,(2007) , 10.1002/ANIE.200701058

Jun Wang, Stephen M. Soisson, Katherine Young, Wesley Shoop, Srinivas Kodali, Andrew Galgoci, Ronald Painter, Gopalakrishnan Parthasarathy, Yui S. Tang, Richard Cummings, Sookhee Ha, Karen Dorso, Mary Motyl, Hiranthi Jayasuriya, John Ondeyka, Kithsiri Herath, Chaowei Zhang, Lorraine Hernandez, John Allocco, Ángela Basilio, José R. Tormo, Olga Genilloud, Francisca Vicente, Fernando Pelaez, Lawrence Colwell, Sang Ho Lee, Bruce Michael, Thomas Felcetto, Charles Gill, Lynn L. Silver, Jeffery D. Hermes, Ken Bartizal, John Barrett, Dennis Schmatz, Joseph W. Becker, Doris Cully, Sheo B. Singh, Platensimycin is a selective FabF inhibitor with potent antibiotic properties Nature. ,vol. 441, pp. 358- 361 ,(2006) , 10.1038/NATURE04784

Srinivas Kodali, Andrew Galgoci, Katherine Young, Ronald Painter, Lynn L. Silver, Kithsiri B. Herath, Sheo B. Singh, Doris Cully, John F. Barrett, Dennis Schmatz, Jun Wang, Determination of selectivity and efficacy of fatty acid synthesis inhibitors. Journal of Biological Chemistry. ,vol. 280, pp. 1669- 1677 ,(2005) , 10.1074/JBC.M406848200

K. C. Nicolaou, David J. Edmonds, Ang Li, G. Scott Tria, Asymmetric total syntheses of platensimycin. Angewandte Chemie. ,vol. 46, pp. 3942- 3945 ,(2007) , 10.1002/ANIE.200700586

Sheo B. Singh, Kithsiri B. Herath, Jun Wang, Nancy Tsou, Richard G. Ball, Chemistry of platensimycin Tetrahedron Letters. ,vol. 48, pp. 5429- 5433 ,(2007) , 10.1016/J.TETLET.2007.06.009