The Rhamnose Moiety of Solamargine Plays a Crucial Role in Triggering Cell Death by Apoptosis
作者： Li-Ching Chang , Tong-Rong Tsai , Jeh-Jeng Wang , Chun-Nan Lin , Kou-Wha Kuo
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摘要: Solamargine, solasodine and khasianine steroidal alkaloids are utilized to determine the role of carbohydrate moiety in mechanism apoptosis. The C3 side chain solamargine, contains 4'Rha-Glc-Rha2', 4'Rha-Glc H, respectively. Solamargine possessed potent cytotoxicity human hepatoma cells, while was greatly diminished. Nevertheless, only solamargine could induced "sub-G1" apoptotic feature flowcytometry. Thus, 2'Rha may play a crucial triggering cell death by In addition, molecular modeling indicated that adjacent rigid steroid structure, drastically changed dihedral angle glycosidic bond. regulations TNFR I II expression different moieties were also distinct. It implied might alter binding specificity receptors consequently regulate gene manners.
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sci-hub.se 参考文章(16)
MARK J. ARENDS, ANDREW H. WYLLIE, Apoptosis: Mechanisms and Roles in Pathology Experimental pathology. ,vol. 32, pp. 223- 254 ,(1991) , 10.1016/B978-0-12-364932-4.50010-1
Peter Vandenabeele, Wim Declercq, Johan Grooten, Walter Fiers, Bart Vanhaesebroeck, Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells. Journal of Immunology. ,vol. 154, pp. 2904- 2913 ,(1995)
H P Hohmann, M Brockhaus, P A Baeuerle, R Remy, R Kolbeck, A P van Loon, Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors. Journal of Biological Chemistry. ,vol. 265, pp. 22409- 22417 ,(1990) , 10.1016/S0021-9258(18)45720-1
A.H. Wyllie, J.F.R. Kerr, A.R. Currie, Cell death : the significance of apoptosis International Review of Cytology-a Survey of Cell Biology. ,vol. 68, pp. 251- 306 ,(1980) , 10.1016/S0074-7696(08)62312-8
Kim-Hong Gan, Chun-Nan Lin, Shen-Jeu Won, Cytotoxic principles and their derivatives of Formosan Solanum plants. Journal of Natural Products. ,vol. 56, pp. 15- 21 ,(1993) , 10.1021/NP50091A003
B. Daunter, B.E. Cham, Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells. Cancer Letters. ,vol. 55, pp. 209- 220 ,(1990) , 10.1016/0304-3835(90)90121-D
Peter Vandenabeele, Wim Declercq, Rudi Beyaert, Walter Fiers, Two tumour necrosis factor receptors: structure and function. Trends in Cell Biology. ,vol. 5, pp. 392- 399 ,(1995) , 10.1016/S0962-8924(00)89088-1
Kou-Wha Kuo, Maria FKL Leung, Wai-Choi Leung, Identification and characterization of an RNA specific primer for human tumor necrosis factor receptor I (TNFR-I). Iubmb Life. ,vol. 40, pp. 119- 125 ,(1996) , 10.1080/15216549600201602
Chun-Nan Lin, Chai-Ming Lu, Ming-Kung Cheng, Kim-Hong Gan, Shen-Jeu Won, The cytotoxic principles of Solanum incanum. Journal of Natural Products. ,vol. 53, pp. 513- 516 ,(1990) , 10.1021/NP50068A041
J. F. R. Kerr, Shrinkage necrosis: a distinct mode of cellular death. The Journal of Pathology. ,vol. 105, pp. 13- 20 ,(1971) , 10.1002/PATH.1711050103