Neoadjuvant Targeted Molecular Therapy Before Renal Surgery

作者: Sumi Dey , Henry N. Peabody , Sabrina L. Noyes , Brian R. Lane

DOI: 10.1016/J.UCL.2016.12.014

关键词:

摘要: Abstract Neoadjuvant targeted molecular therapy may benefit select patients with metastatic renal cell carcinoma. The primary use of this in disease is to reduce tumor burden, prevent distant metastasis, and increase overall survival. size complexity, facilitate partial nephrectomy rather than radical nephrectomy, downstage thrombus facilitating thrombectomy, make unresectable tumors resectable when applied selected patients. These potential benefits neoadjuvant require further clinical trials better define the function oncological survival outcomes receiving each active agent.

参考文章(55)
Jonathan L. Silberstein, Frederick Millard, Reza Mehrazin, Ryan Kopp, Wassim Bazzi, Christopher J. DiBlasio, Anthony L. Patterson, Tracy M. Downs, Furhan Yunus, Christopher J. Kane, Ithaar H. Derweesh, Feasibility and efficacy of neoadjuvant sunitinib before nephron‐sparing surgery BJUI. ,vol. 106, pp. 1270- 1276 ,(2010) , 10.1111/J.1464-410X.2010.09357.X
Futoshi Sano, Kazuhide Makiyama, Tomoyuki Tatenuma, Ryoko Sakata, Hiroyuki Yamanaka, Syusei Fusayasu, Takashi Nakayama, Noboru Nakaigawa, Masahiro Yao, Yoshinobu Kubota, Presurgical downstaging of vena caval tumor thrombus in advanced clear cell renal cell carcinoma using temsirolimus International Journal of Urology. ,vol. 20, pp. 637- 639 ,(2013) , 10.1111/IJU.12012
Hiral Parekh, Brian I Rini, Emerging therapeutic approaches in renal cell carcinoma. Expert Review of Anticancer Therapy. ,vol. 15, pp. 1305- 1314 ,(2015) , 10.1586/14737140.2015.1090315
Jose A. Karam, Catherine E. Devine, Bryan M. Fellman, Diana L. Urbauer, E. Jason Abel, Mohamad E. Allaf, Axel Bex, Brian R. Lane, R. Houston Thompson, Christopher G. Wood, Variability of inter‐observer agreement on feasibility of partial nephrectomy before and after neoadjuvant axitinib for locally advanced renal cell carcinoma (RCC): independent analysis from a phase II trial BJUI. ,vol. 117, pp. 629- 635 ,(2016) , 10.1111/BJU.13188
Brian R. Lane, Sevag Demirjian, Ithaar H. Derweesh, Toshio Takagi, Zhiling Zhang, Lily Velet, Cesar E. Ercole, Amr F. Fergany, Steven C. Campbell, Survival and Functional Stability in Chronic Kidney Disease Due to Surgical Removal of Nephrons: Importance of the New Baseline Glomerular Filtration Rate European Urology. ,vol. 68, pp. 996- 1003 ,(2015) , 10.1016/J.EURURO.2015.04.043
Axel Bex, Astrid A. M. van der Veldt, Christian Blank, Alfons J. M. van den Eertwegh, Epie Boven, Simon Horenblas, John Haanen, Neoadjuvant sunitinib for surgically complex advanced renal cell cancer of doubtful resectability: initial experience with downsizing to reconsider cytoreductive surgery World Journal of Urology. ,vol. 27, pp. 533- 539 ,(2009) , 10.1007/S00345-008-0368-7
David A. Kunkle, Naomi B. Haas, Robert G. Uzzo, Adjuvant therapy for high-risk renal cell carcinoma patients. Current Urology Reports. ,vol. 8, pp. 19- 30 ,(2007) , 10.1007/S11934-007-0017-5
Yushi Zhang, Yongqiang Li, Jianhua Deng, Zhigang Ji, Hongyan Yu, Hanzhong Li, Sorafenib Neoadjuvant Therapy in the Treatment of High Risk Renal Cell Carcinoma PLOS ONE. ,vol. 10, pp. e0115896- ,(2015) , 10.1371/JOURNAL.PONE.0115896
N. Kroeger, M. Gajda, J. Zanow, I. Petersen, U. Settmacher, H. Wunderlich, T. Steiner, Downsizing a tumor thrombus of advanced renal cell carcinoma with neoadjuvant systemic therapy and resulting histopathological effects Urologia Internationalis. ,vol. 84, pp. 479- 484 ,(2010) , 10.1159/000296301
Nicholas J. Hellenthal, Willie Underwood, Remedios Penetrante, Alan Litwin, Shaozeng Zhang, Gregory E. Wilding, Bin T. Teh, Hyung L. Kim, Prospective Clinical Trial of Preoperative Sunitinib in Patients With Renal Cell Carcinoma Journal of Urology. ,vol. 184, pp. 859- 864 ,(2010) , 10.1016/J.JURO.2010.05.041