HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

摘要: Red blood cells use a molecule called hemoglobin to transport oxygen around the body. To make hemoglobin, require iron build component heme. If an individual does not get enough in their diet, body cannot produce red cells, or lack hemoglobin. This condition is known as deficiency anemia, and it affects one-third of world’s population. Researchers did know exactly how levels control cell production, though several proteins had been identified play important roles. Heme forms cell's mitochondria: compartments that supply with energy. When heme developing are low, protein HRI reduces production many proteins, most importantly up also boosts ATF4, which switches on set genes help both its mitochondria adapt In turn, ATF4 reduce activity signaling pathway mTORC1, controls grow divide. understand more detail regulate new Zhang et al. looked at immature from livers mice. Some mice lacked gene produces HRI, some experienced deficiency. Comparing different revealed iron-deficient mice, largely rate wider cell. At same time, increased allows carry releasing energy continue developing. found inhibits mTORC1 needs be active for mature. Overall, results suggest drugs activate block could treat anemia. The next step test effects such have anemic people.