Transcription Profiling of Brain Tumors: Tumor Biology and Treatment Stratification

摘要: The spectrum and diversity of primary brain tumors has made prognostic determinations based purely on clinicopathologic variables inexact. For the most frequently occurring lethal tumors, malignant astrocytomas, use large-scale gene expression profiling experiments led to a better understanding biology these giving insights into their origin development, as well more powerful outcome prediction. It also paved way for possibility personalized medicine, where patient’s tumor profile can be used design treatment specific that individual with greatest response. This chapter will focus development transcriptional profiles biomarkers response in patients tumors. discussion limited array-based profiling, other techniques, such serial analysis (SAGE), have had less widespread (Ljubimova et al. 2001a; Boon 2003; Riggins Beaty 2007; Kavsan 2007). While mRNA-based been described variety affect central nervous system, this particularly gliomas, which majority efforts focused date, both due larger populations available analyses poorer devastating (Kleihues 2000; Behin 2003).