Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer.
作者： Renat Shaykhiev , Rui Wang , Rachel K. Zwick , Neil R. Hackett , Roland Leung
DOI: 10.1002/STEM.1459
关键词:
摘要: Activation of the human embryonic stem cell (hESC) signature genes has been observed in various epithelial cancers. In this study, we found that hESC is selectively induced airway basal stem/progenitor population healthy smokers (BC-S), with a pattern similar to activated all major types lung cancer. We further identified subset 6 BC-S genes, whose coherent overexpression adenocarcinoma (AdCa) was associated reduced function, poorer differentiation grade, more advanced tumor stage, remarkably shorter survival, and higher frequency TP53 mutations. shared considerable carcinomas common inactivation molecular which strongly correlated gene expression. These data provide transcriptome-based evidence smoking-induced reprogramming BC toward hESC-like phenotype might represent early event development aggressive humans. Stem Cells 2013;31:1992-2002
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