Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice Through Modulation of Mitochondrial Respiration.

摘要: Cognitive decline is observed in aging and neurodegenerative diseases, including Alzheimer’s disease (AD) dementia. Intracellular energy produced via mitochondrial respiration used the regulation of synaptic plasticity structure, dendritic spine length density, as well for release neurotrophic factors involved learning memory. To date, a few synthetic agents improving function have been developed overcoming cognitive impairment. However, no natural compounds that modulate by directly targeting mitochondria developed. Here, we demonstrate mixture Schisandra chinensis extract (SCE) ascorbic acid (AA) improved induced plasticity-regulating proteins enhancing respiration. Treatment embryonic mouse hippocampal mHippoE-14 cells with 4:1 SCE AA increased basal oxygen consumption rate. We found mice injected SCE-AA showed enhanced memory recognition ability. further injection significantly expression postsynaptic density protein 95 (PSD95), an increase was correlated brain-derived factor (BDNF) expression. These results improves memory, suggesting this compound could be to alleviate AD aging-associated decline.