Standard treatment of ulcerative colitis.

摘要: Ulcerative colitis (UC) is an idiopathic, chronic inflammation of the colon which may present with a range mild to severe symptoms. The disease be localized rectum or can more extensive and involve left side whole colon. Treatment in UC directed towards inducing maintaining remission symptoms mucosal inflammation. key parameters assessed for most appropriate treatment are severity extent Meta-analyses published trials have shown that topical 5-aminosalicylic acid (5-ASA) choice active distal mild-to-moderate UC. Oral aminosalicylates effective both disease, but rates lower than those obtained 5-ASA. New steroids, such as budesonide beclomethasone dipropionate (BDP), administered enemas, constitute alternative 5-ASA therapy. In some studies, these been conventional steroids significantly inhibition plasma cortisol levels. Patients unresponsive presentation will require oral corticosteroids sometimes intravenous Approximately 10% patients attacks requiring hospitalization. should managed jointly by medical surgical team, intensive started high-dose steroids. Early recognition failure therapy allow introduction immunosuppressive cyclosporine. who respond shifted cyclosporine associated azathioprine/6-mercaptopurine, whereas fail proctocolectomy. first-line maintenance remission. Topical play role disease. steroid dependent on azathioprine 6-mercaptopurine although it take up 3 months become effective. They reversible immediate effects, pancreatitis bone marrow suppression, disappear upon discontinuation Close monitoring hematologic biochemical improve safety. use biologic infliximab has not established.