Asymmetric polyurethane membrane with inflammation-responsive antibacterial activity for potential wound dressing application

摘要: By combining solvent evaporation with wet phase inversion technique, an asymmetric polyurethane membrane (ASPU) was constructed from a sulfanilamide-conjugated PU, as potential candidate for wound dressing application. As result of the combined membrane-formation method, ASPU constituted by integral and dense skin layer supported porous sublayer. The found impermeable to pathogenic organisms, while sublayer intended draining excessive exudates. Compared typical PU dressings commercially available, exhibited reasonable moisture vapor transmission rate, well significantly improved gas circulation exudate absorption capabilities, which synergistically optimized microenvironment proper healing. Furthermore, constituting designed susceptible urease, representative hydrolase derived inflammation-causing pathogens. In presence urea linkages adjacent sulfanilamide monomeric units were catalytically cleaved, enabling release free antibiotic that held pharmacological activity membrane. When incubated without those cleavage sites substantially high resistance against hydrolysis so no detected throughout incubation period. this inflammation-responsive manner, anti-inflammatory efficiency antibiotics enhanced, undesirable side effects associated abuse minimized. Cell culture assay further revealed displayed cytotoxicity toward normal human dermis fibroblasts, suggesting biocompatible potential. Based on these results, multifunctional in study might be clinically suitable ideal biomedical care.