Intensive induction-sequential chemotherapy with BOP/VIP-B compared with Treatment with BEP/EP for poor-prognosis metastatic nonseminomatous germ cell tumor : A randomized Medical Research council/European organization for Research and Treatment of Cancer study
作者： S B Kaye , G M Mead , S Fossa , M Cullen , R deWit
DOI: 10.1200/JCO.1998.16.2.692
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摘要: PURPOSEThe aim of this randomized trial was to assess the potential therapeutic advantage an intensive induction-sequential chemotherapy schedule (bleomycin, vincristine, cisplatin [BOP])/etoposide, ifosfamide, cisplatin, and bleomycin [VIP-B]), compared with a regimen based on bleomycin, etoposide, (BEP) (BEP/etoposide [EP]) for treatment patients poor-prognosis metastatic nonseminomatous germ cell tumors (NSGCTs).PATIENTS AND METHODSPatients had one or more following: retroperitoneal mass > = 10 cm in diameter; mediastinal supraclavicular 5 at least 20 lung metastases (any size); liver, bone, brain metastases; serum beta human chorionic gonadotropin (betaHCG) 10,000 IU/L alfa fetoprotein (AFP) 1,000 IU/L. A total 380 were accrued between May 1990 June 1994 into joint Medical Research Council (MRC)/European Organization Treatment Cancer (EORTC) trial; t...
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