Migration of the schistosomula of Schistosoma mansoni in mice vaccinated with radiation-attenuated cercariae, and normal mice: an attempt to identify the timing and site of parasite death.

摘要: The migration of the schistosomula Schistosoma mansoni labelled with [75Se]methionine, has been followed from skin to hepatic portal system. Parasites were detected in all mouse tissues by compressed organ autoradiography. Two separate experiments performed track parasites normal mice, and mice previously vaccinated irradiated cercariae. In profile numbers autoradiographic foci skin, lungs, systemic splanchnic organs was described time post-infection. distribution organs, following exit paralleled fractional cardiac output. Accumulation system complete day 21 Only 2-3 passes around vascular would be required produce population. No significant decline total first 12 days majority parasite elimination appeared occur lungs as late 21, lesser proportions infection site. pattern similar that animals. One difference observed longer duration stay skin; however, eventually reached lungs. phase occurred on a reduced scale, did accumulation commenced approximately 7 earlier than proceeded lower end-point. Again It is suggested resistance reinfection two additive components which combine retard within vasculature, preventing them reaching protal