Mouse models of cognitive disabilities in trisomy 21 (Down syndrome)
作者： Pierre L. Roubertoux , Michèle Carlier
DOI: 10.1002/AJMG.C.30280
关键词:
摘要: Trisomy 21 (TRS21), also referred to as Down syndrome, occurs once in every 800–1,000 live births. It is the consequence of an extra copy HSA21 that causes imbalanced gene dose effect. TRS21 first known genetic cause cognitive disability. The syndrome complex, and includes various cardiac, immune, bone disorders. Most these signs are highly variable expression but disability most constant characteristic persons with TRS21. syntenies exist between three mouse chromosomes (MMU10, MMU16, MMU17) offer opportunity for a genotype–phenotype correlation. We present here segmental trisomies available we discuss their contribution brain phenotypes © 2010 Wiley-Liss, Inc.
sci-hub.se 参考文章(103)
Jessica K. Roder, John C. Roder, Robert Gerlai, Memory and the effect of cold shock in the water maze in S100β transgenic mice Physiology & Behavior. ,vol. 60, pp. 611- 615 ,(1996) , 10.1016/S0031-9384(96)80038-2
H. Sago, E. J. Carlson, D. J. Smith, J. Kilbridge, E. M. Rubin, W. C. Mobley, C. J. Epstein, T.-T. Huang, Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 6256- 6261 ,(1998) , 10.1073/PNAS.95.11.6256
Melissa R Stasko, Alberto C.S Costa, Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behavioural Brain Research. ,vol. 154, pp. 1- 17 ,(2004) , 10.1016/J.BBR.2004.01.012
Robin S. Chapman, Linda J. Hesketh, Behavioral phenotype of individuals with Down syndrome. Mental Retardation and Developmental Disabilities Research Reviews. ,vol. 6, pp. 84- 95 ,(2000) , 10.1002/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P
Alberto C.S. Costa, Michael J. Grybko, Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Neuroscience Letters. ,vol. 382, pp. 317- 322 ,(2005) , 10.1016/J.NEULET.2005.03.031
Roger H. Reeves, Nicholas G. Irving, Timothy H. Moran, Anny Wohn, Cheryl Kitt, Sangram S. Sisodia, Cecilia Schmidt, Roderick T. Bronson, Muriel T. Davisson, A mouse model for Down syndrome exhibits learning and behaviour deficits Nature Genetics. ,vol. 11, pp. 177- 184 ,(1995) , 10.1038/NG1095-177
Robert Lyle, Frédérique Béna, Sarantis Gagos, Corinne Gehrig, Gipsy Lopez, Albert Schinzel, James Lespinasse, Armand Bottani, Sophie Dahoun, Laurence Taine, Martine Doco-Fenzy, Pascale Cornillet-Lefèbvre, Anna Pelet, Stanislas Lyonnet, Annick Toutain, Laurence Colleaux, Jürgen Horst, Ingo Kennerknecht, Nobuaki Wakamatsu, Maria Descartes, Judy C Franklin, Lina Florentin-Arar, Sophia Kitsiou, Emilie Aït Yahya-Graison, Maher Costantine, Pierre-Marie Sinet, Jean M Delabar, Stylianos E Antonarakis, Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21 European Journal of Human Genetics. ,vol. 17, pp. 454- 466 ,(2009) , 10.1038/EJHG.2008.214
P. Bianchi, E. Ciani, S. Guidi, S. Trazzi, D. Felice, G. Grossi, M. Fernandez, A. Giuliani, L. Calza, R. Bartesaghi, Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome The Journal of Neuroscience. ,vol. 30, pp. 8769- 8779 ,(2010) , 10.1523/JNEUROSCI.0534-10.2010
Heather A Bimonte-Nelson, Christopher L Hunter, Matthew E Nelson, Ann-Charlotte E Granholm, Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behavioural Brain Research. ,vol. 139, pp. 47- 57 ,(2003) , 10.1016/S0166-4328(02)00082-7
Haruhiko Sago, Elaine J Carlson, Desmond J Smith, Edward M Rubin, Linda S Crnic, Ting-Ting Huang, Charles J Epstein, Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatric Research. ,vol. 48, pp. 606- 613 ,(2000) , 10.1203/00006450-200011000-00009