Chemical constituents of Heteroplexis micocephala.
作者： Xiaona Fan , Jiachen Zi , Chenggen Zhu , Wendong Xu , Wei Cheng
DOI: 10.1021/NP900213W
关键词:
摘要: Eleven new compounds including two sesquiterpenes with an unusual 2,2,5,9-tetramethylbicyclo[6.3.0]undecane carbon skeleton (1 and 2), five phytane-type diterpene dilactones (3-7), ent-clerodane dilactone (8), three phenylpropenol esters (9-11), together a diacylphenol (12) 38 known compounds, have been isolated from ethanolic extract of Heteroplexis micocephala. Their structures absolute configurations were elucidated by spectroscopic chemical analyses. In the in vitro assays, compound 6 showed selective cytotoxic activity against A2780 IC(50) value 4.37 microM, while sinapyl diangelate (13) potent inhibiting HIV-1 replication 4.04 microM.
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