Increased levels of serum neoprotein and decreased production of neutrophil superoxide anions in chronic heart failure with elevated levels of tumor necrosis factor-alpha

摘要: Abstract Objectives . The purpose of this study was to examine the role tmor necrosis factor-alpha and tetrahydrobiopterin superoxide anion release from neutrophils in severe chronic heart failure. Background Previous studies have demonstrated elevated production tumor free radical-induced endothelial cell damage Methods Plasma serum levels immunoreactive interleukin-1, interleukin-6, interferon-gamma, neoprotein anions circulating both at basal conditions after triggering with f-Met-Leu-Phe or phorbol 12-myristate 13-acetate were measured 16 patients failure 11 healthy control subjects. Results Circulating compared values A significant correlation between two found. Basal phorbolester-triggered oxygen radicals not affected However, formylpeptide-stimulated by significantly reduced. Conclusions Suppressed neutrophil function exhibiting necrosis-alpha factor may indicate self-protection against deleterious effects neutrophil-derived radicals. Through induction synthesis (as reflected neoprotein), affect nitric oxide synthesis.