Developmental Models for Wound Healing

摘要: The bodies of animals and humans frequently sustain damage as a result injury or disease, the ability to repair this is essential for life. Tissue repair, wound healing, complex process which difficult study experimentally is, therefore, not fully understood. Over recent years, various studies have identified striking similarities between tissue morphogenesis in tissues are originally formed during embryonic development. This has raised possibility using developmental processes model systems help better understanding repair. article describes how comparative improved mechanisms further discusses key regulatory that shared development including important developments field. Key Concepts: The behaviour cells damaged often parallels observed when initially embryogenesis. Developmental such Drosophila dorsal closure mouse eyelid can be used models healing. Common cytoskeletal signalling machineries regulate cell reepithelialisation episode healing also epithelial events. Key regulators include Rho GTPases, JNK cascade planar polarity pathway. Coordinated collective migration many necessary both remodelling. Mechanical seems remodelling, but its molecular still largely remain elusive. Inflammatory play instructive roles remodelling. Novel techniques advanced bioimaging mathematical modelling will uncover general underpinning remodelling. Keywords: wound healing; similarities formation repair; dorsal closure; eyelid closure; neural tube closure; Rho GTPases; JNK; planar (PCP) pathway; collective migration; biomechanics