Elucidation of release characteristics of highly soluble drug trimetazidine hydrochloride from chitosan-carrageenan matrix tablets.
作者： Liang Li , Linlin Wang , Yang Shao , Y.E. Tian , Conghao Li
DOI: 10.1002/JPS.23632
关键词:
摘要: The aim of this study was to better understand the underlying drug release characteristics from matrix tablets based on combination chitosan (CS) and different types carrageenans [kappa (κ)-CG, iota (ι)-CG, lambda (λ)-CG]. Highly soluble trimetazidine hydrochloride (TH) used as a model drug. First, formulations were investigated, then in situ complexation capacity CG with TH CS studied by differential scanning calorimetry Fourier transform infrared spectroscopy. Erosion swelling also characterized drug-release mechanisms. Effects pH ionic strength studied. It found that not only ι-CG λ-CG could reduce burst effect TH-CG interaction, CS-ι-CG- CS-λ-CG-based polyelectrolyte film further modify controlled-release behavior, but CS-κ-CG. High high resulted faster CS-κ-CG- CS-ι-CG-based matrix, less sensitive strength. In conclusion, are quite promising carrier multiple
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