Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
作者： Jenny Meinhardt , Josefine Radke , Carsten Dittmayer , Jonas Franz , Carolina Thomas
DOI: 10.1038/S41593-020-00758-5
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摘要: … olfactory mucosa, its nervous projections and several defined CNS regions in 33 individuals … in b, purple in c) and nervous tissue characterized by nerve fibers immunoreactive for S100 …
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Marc Desforges, Alain Le Coupanec, Élodie Brison, Mathieu Meessen-Pinard, Pierre J. Talbot, Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans. Advances in Experimental Medicine and Biology. ,vol. 807, pp. 75- 96 ,(2014) , 10.1007/978-81-322-1777-0_6
Debby van Riel, Rob Verdijk, Thijs Kuiken, The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system. The Journal of Pathology. ,vol. 235, pp. 277- 287 ,(2015) , 10.1002/PATH.4461
Emmanuelle Blanchard, Philippe Roingeard, Virus‐induced double‐membrane vesicles Cellular Microbiology. ,vol. 17, pp. 45- 50 ,(2015) , 10.1111/CMI.12372
Michael Laue, Electron Microscopy of Viruses Methods in Cell Biology. ,vol. 96, pp. 1- 20 ,(2010) , 10.1016/S0091-679X(10)96001-9
Lindsay A Carter, Jessica L MacDonald, A Jane Roskams, Olfactory Horizontal Basal Cells Demonstrate a Conserved Multipotent Progenitor Phenotype The Journal of Neuroscience. ,vol. 24, pp. 5670- 5683 ,(2004) , 10.1523/JNEUROSCI.0330-04.2004
James E. Schwob, Neural regeneration and the peripheral olfactory system. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 269, pp. 33- 49 ,(2002) , 10.1002/AR.10047
Cynthia S. Goldsmith, Kathleen M. Tatti, Thomas G. Ksiazek, Pierre E. Rollin, James A. Comer, William W. Lee, Paul A. Rota, Bettina Bankamp, William J. Bellini, Sherif R. Zaki, Ultrastructural characterization of SARS coronavirus. Emerging Infectious Diseases. ,vol. 10, pp. 320- 326 ,(2004) , 10.3201/EID1002.030913
Jason Netland, David K. Meyerholz, Steven Moore, Martin Cassell, Stanley Perlman, Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. Journal of Virology. ,vol. 82, pp. 7264- 7275 ,(2008) , 10.1128/JVI.00737-08
Thomas G Ksiazek, Dean Erdman, Cynthia S Goldsmith, Sherif R Zaki, Teresa Peret, Shannon Emery, Suxiang Tong, Carlo Urbani, James A Comer, Wilina Lim, Pierre E Rollin, Scott F Dowell, Ai-Ee Ling, Charles D Humphrey, Wun-Ju Shieh, Jeannette Guarner, Christopher D Paddock, Paul Rota, Barry Fields, Joseph DeRisi, Jyh-Yuan Yang, Nancy Cox, James M Hughes, James W LeDuc, William J Bellini, Larry J Anderson, SARS Working Group, A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome New England Journal of Medicine. ,vol. 348, pp. 1953- 1966 ,(2003) , 10.1056/NEJMOA030781
Eric H. Holbrook, Enming Wu, William T. Curry, Derrick T. Lin, James E. Schwob, Immunohistochemical characterization of human olfactory tissue Laryngoscope. ,vol. 121, pp. 1687- 1701 ,(2011) , 10.1002/LARY.21856