Serine/threonine kinase inhibitors

作者: Jonas Grina , Rustam Ferdinand Garrey , Aihe Zhou , Huifen Chen , Kirk Robarge

DOI:

关键词:

摘要: Compounds of Formula I or a stereoisomer, tautomer, prodrug pharmaceutically acceptable salt thereof are provided, which useful for the treatment hyperproliferative, pain and inflammatory diseases. Methods using compounds thereof, in vitro, situ, vivo diagnosis, prevention such disorders mammalian cells, associated pathological conditions disclosed.

参考文章(149)
Gaetan Ladouceur, Barton Phillips, Cheng Bi, Olaf Weber, James Cook, Yuanwei Chen, Jianqing Chen, Lin Yi, Sharad K. Verma, Stephen Boyer, Jianmei Fan, Jennifer Burke, Roger B. Clark, Chunguang Wang, Michael J. Burke, Dhanapalan Nagarathnam, 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer ,(2002)
Michael R. Wyler, Deborah H. Smith, Eftihia Cayanis, Udo Többen, Nathalie Aulner, Thomas Mayer, Cell-Based Assays to Probe the ERK MAP Kinase Pathway in Endothelial Cells Methods in Molecular Biology. ,vol. 486, pp. 29- 41 ,(2009) , 10.1007/978-1-60327-545-3_3
Paul Knochel, Gary A. Molander, Comprehensive organic synthesis Elsevier. ,(2014)
Ernest Ludwig Eliel, Samuel H. Wilen, Lewis N. Mander, Stereochemistry of Organic Compounds ,(1962)
Bruce D. Cheson, Chronic Lymphoid Leukemias ,(2001)
W. J. Lough, Chiral Liquid Chromatography ,(1989)
Michiaki Kohno, Jacques Pouyssegur, Pharmacological inhibitors of the ERK signaling pathway: application as anticancer drugs. Progress in cell cycle research. ,vol. 5, pp. 219- 224 ,(2003)
Shuang Chen, Geoff G. Zhang, Nathaniel D. Catron, Yuchuan Gong, Salts and crystalline forms of an apoptosis-inducing agent ,(2011)
John Gaudino, Rustam Ferdinand Garrey, James F. Blake, Eli M. Wallace, Huifen Chen, Samuel Kintz, Lewis Gazzard, Mark Joseph Chicarelli, Jason Demeese, David A. Moreno, Robert J. Kaus, Christopher S. Siedem, Jacob Schwarz, Peter J. Mohr, Quinazoline compounds as serine/threonine kinase inhibitors ,(2012)
He Zhao, Jun Yuan, Shaojing Hu, Hongbin Li, Qin Guo, Jianmin Mao, Darren Whitehouse, Jack Hammer, David Wustrow, Wallace Fringle, George Maynard, Subtituted heteroaryl cb1 antagonists ,(2006)