4 Immune aspects of pathology of the placental bed contributing to pregnancy pathology

摘要: Summary Interest has recently focused on the role of placental bed in pathogenesis a variety pregnancy disorders. Considerable advances have been made understanding complex relationships between maternal and fetal trophoblast normal pregnancy. Invasion uterine spiral arteries by extravillous effects physiological changes required to accommodate increased blood flow fetoplacental unit. Control invasion may depend intrinsic properties, such as production proteolytic enzymes expression non-classical class I MHC antigen, but cells within decidua also play role. Leukocytes form major component human decidualized endometrium first trimester consist granulated lymphocytes, macrophages T lymphocytes. Suggested roles for leukocytes include natural killer cell activity, cytokine secretion, antigen presentation immunosuppression. Several disorders, including pre-eclampsia intrauterine growth retardation, be due abnormal maternofetal cellular causing inadequate acute atherosis. However, immunological factors these disorders is uncertain since deposition immunoglobulins complement detected Placenta accreta reflect undue invasiveness immunohistochemical studies subinvolution uteroplacental suggest an relationship bed. Although vivo decidual not known, infertile reported deficiency suggesting possible early implantation placentation. Granulated lymphocytes loss. There considerable which can lead aetiology various clinical conditions unlikely fully established until regulatory mechanisms are elucidated.