Small molecules and their controlled release that induce the osteogenic/chondrogenic commitment of stem cells.
作者： Yingjun Wang , Guanglin Zhu , Nanying Li , Juqing Song , Lin Wang
DOI: 10.1016/J.BIOTECHADV.2015.08.005
关键词:
摘要: Stem cell-based tissue engineering plays a significant role in skeletal system repair and regenerative therapies. However, stem cells must be differentiated into specific mature prior to implantation (direct may lead tumour formation). Natural or chemically synthesised small molecules provide an efficient, accurate, reversible, cost-effective way differentiate compared with bioactive growth factors gene-related methods. Thus, investigating the influences of on differentiation is great significance. Here, we review series that can induce or/and promote osteogenic/chondrogenic commitment cells. The controlled release these from various vehicles for therapies applications also discussed. extensive studies this field represent contributions research medicine.
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