Splicing: is there an alternative contribution to Parkinson’s disease?
作者： Valentina La Cognata , Velia D’Agata , Francesca Cavalcanti , Sebastiano Cavallaro
DOI: 10.1007/S10048-015-0449-X
关键词:
摘要: Alternative splicing is a crucial mechanism of gene expression regulation that enormously increases the coding potential our genome and represents an intermediate step between messenger RNA (mRNA) transcription protein posttranslational modifications. occupies central position in development functions nervous system. Therefore, its deregulation frequently leads to several neurological human disorders. In present review, we provide updated overview on impact alternative Parkinson’s disease (PD), second most common neurodegenerative disorder worldwide. We will describe major PD-linked genes by collecting current evidences about this intricate not carefully explored aspect. Assessing role PD pathobiology may represent toward improved understanding complex disease.
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