Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate.
作者： Richard A. Morrisett , David Martin , Wilkie A. Wilson , Daniel D. Savage , H.Scott Swartzwelder
DOI: 10.1016/0741-8329(89)90013-X
关键词:
摘要: Morphological, neurochemical, and electrophysiological studies suggest that the hippocampal formation is one of brain regions most sensitive to teratological consequences prenatal exposure ethanol. We now report ethanol results in a reduction sensitivity hippocampi adult offspring N-methyl-D-aspartate (NMDA). Moreover, it appears reduced NMDA from abnormal magnesium regulation receptor-channel complex. These deficits function may underlie some behavioral learning which are characteristic mothers consume even moderate amounts during pregnancy.
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