Hypnotics and sedatives

摘要: Publisher Summary This chapter discusses several adverse effects of hypnotics and sedatives. The reduction in the use barbiturates over past years has sharply reduced number deaths, particularly suicides, from barbiturate overdose. However, only a very small decline can be detected overall drug suicide rate. extent to which normal dosage benzodiazepines actually produces addiction is unknown, but should suspected when patient repeatedly tries wean himself benzodiazepine restarts treatment because headache, dysphoria, or symptoms unrelated initial anxiety syndrome. Triazolam, short-acting hypnotic, was recently temporarily withdrawn market Netherlands Luxemburg reported side such as severe malaise, depersonalization, depression, cervical pains, impaired motor function, blurred vision, dysfunctional speaking writing, suicidal tendencies. phenomena receptor-site tolerance adaptation greatly complicate interpretation blood levels pharmacokinetics relation clinical effect. A given level may have one effect at time different later after period exposure elapsed. It conceivable that concentrations pharmacokinetic properties bear type relationship non-specific sedative effects, an entirely anti-anxiety effects.