Interleukin-1 receptor antagonist prevents sepsis-induced inhibition of protein synthesis

摘要: To understand the role of interleukin-1 (IL-1) as a mediator sepsis-induced skeletal muscle catabolism, we investigated effects specific IL-1 receptor antagonist (IL-1ra) on protein metabolism in rodent model chronic abdominal sepsis. A constant infusion IL-1ra (2 mg.kg-1.h-1) or saline was begun immediately after induction sepsis and continued for 5 days. The effect examined individual muscles (gastrocnemius, soleus, heart) containing different fiber types. Infusion control animals did not alter any examined. Muscle weight, content, rate synthesis gastrocnemius were reduced by sepsis, whereas none these parameters affected soleus heart. prevented loss inhibition but without restored translational efficiency septic rats RNA content. These results provide evidence abnormalities metabolism.