CAR and PXR: Xenosensors of endocrine disrupters?
作者： Xiomara C. Kretschmer , William S. Baldwin
DOI: 10.1016/J.CBI.2005.06.003
关键词:
摘要: … PXR and CAR received their names because of steroid ligands that activate and inhibit their … nonylphenol activate either PXR or both PXR and CAR. Because PXR and CAR are …
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L. Payen, L. Sparfel, A. Courtois, L. Vernhet, A. Guillouzo, O. Fardel, The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds. Cell Biology and Toxicology. ,vol. 18, pp. 221- 233 ,(2002) , 10.1023/A:1016020626941
Ping Wei, Jun Zhang, Margarete Egan-Hafley, Shuguang Liang, David D. Moore, The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature. ,vol. 407, pp. 920- 923 ,(2000) , 10.1038/35038112
David J. Waxman, Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. Biochemical Pharmacology. ,vol. 37, pp. 71- 84 ,(1988) , 10.1016/0006-2952(88)90756-3
G. Vogel, PHARMACOLOGY: A Worrisome Side Effect of an Antianxiety Remedy Science. ,vol. 291, pp. 37- 37 ,(2001) , 10.1126/SCIENCE.291.5501.37
J Schneider, M M Huh, H L Bradlow, J Fishman, Antiestrogen action of 2-hydroxyestrone on MCF-7 human breast cancer cells. Journal of Biological Chemistry. ,vol. 259, pp. 4840- 4845 ,(1984) , 10.1016/S0021-9258(17)42922-X
Barry M. Forman, Iphigenia Tzameli, Hueng-Sik Choi, Jasmine Chen, Devendranath Simha, Wongi Seol, Ronald M. Evans, David D. Moore, Androstane metabolites bind to and deactivate the nuclear receptor CAR-β Nature. ,vol. 395, pp. 612- 615 ,(1998) , 10.1038/26996
G. Vogel, PHARMACOLOGY: How the Body's 'Garbage Disposal' May Inactivate Drugs Science. ,vol. 291, pp. 35- 37 ,(2001) , 10.1126/SCIENCE.10.1126/SCIENCE.291.5501.35
Curtis D. Klaassen, Yaping Liu, Jeff Staudinger, Ajay Madan, Sultan Habeebu, Coordinate Regulation of Xenobiotic and Bile Acid Homeostasis by Pregnane X Receptor Drug Metabolism and Disposition. ,vol. 29, pp. 1467- 1472 ,(2001)
Kevin W. Gaido, Susan C. Maness, Donald P. McDonnell, Shangara S. Dehal, David Kupfer, Stephen Safe, Interaction of Methoxychlor and Related Compounds with Estrogen Receptor α and β, and Androgen Receptor: Structure-Activity Studies Molecular Pharmacology. ,vol. 58, pp. 852- 858 ,(2000) , 10.1124/MOL.58.4.852
Laurence N. Kolonel, H. Leon Bradlow, Thomas R. Fears, Daniel W. Sepkovic, Malcolm C. Pike, Anna H. Wu, Roni T. Falk, Dee W. West, Regina G. Ziegler, Abraham M.Y. Nomura, Xia Xu, Robert N. Hoover, Urinary estrogen metabolites and their ratio among Asian American women. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 14, pp. 221- 226 ,(2005)