Hepatocellular carcinoma in non-alcoholic steatohepatitis: Growing evidence of an epidemic?

摘要: The incidence of hepatocellular carcinoma in non-viral-related chronic liver disease has gradually increased Japan. Obesity and diabetes mellitus type 2 have been established as a significant risk factor for (HCC) by epidemiologic observations experimental studies. risks these factors HCC are likely conferred two factors: the development non-alcoholic steatohepatitis (NASH) carcinogenic potential themselves. Hepatocellular NASH is difficult to evaluate because histological diagnosis required NASH, which can lead selection bias. Furthermore, end-stage effect "burned-out" cannot be made any more. At all events, previous studies on etiology Japanese showed that fatty accounts 1-5% (male predominant, median age 72 years). They high prevalences obesity and/or 10-75% arose from non-cirrhotic livers. may multicentric origin, similar based viral hepatitis. Regular screening extremely important especially cirrhotic patients recurrence should warned. In western Asian countries, prevalence general population increasing dramatically. Therefore, there an urgent need elucidate pathogenesis clinical features NASH. this review we summarize current concepts