Genetic studies of human apolipoproteins. XVIII. Apolipoprotein polymorphisms in Australian Aborigines.

摘要: A tribal aboriginal community, the Mowanjum, from Kimberley region in Western Australia has been screened to determine extent of genetic variation products genes coding for apolipoproteins, which are intimately involved lipid metabolism. Of seven systems tested, APOE and APOH revealed common structural variations, but their distribution patterns significantly different those found European populations. Australian Aborigines were be unique because they have no APOE*2 APOH*3 alleles strikingly high frequencies APOE*4 (26%) APOH*1 (13%) alleles. The contrast observed at these apolipoprotein loci between Europeans not only makes useful markers biologic anthropology studies also provides a opportunity investigate role genetic-environment interaction determining interpopulation differences cardiovascular disease risk factors.