The effect of cyclosporine A on infection of susceptible cells by human immunodeficiency virus type 1.

摘要: The effect of cyclosporine A (CyA) on the ability human immunodeficiency virus type 1 (HIV-1) to infect H-9 T-cell leukemic line, as well interleukin-2 (IL-2)-grown peripheral blood-derived lymphocytes, has been studied. Pretreatment cells and lymphocytes with CyA over 24 hours completely prevented viral infection a 21-day period, whereas addition drug at two postinfection HIV-1 had significant inhibitory replication expression virus-specific antigens p17 p24. However, if was added later times these lymphocytic cells, this lost. Indeed, removal from cultures that treated after led rapid production progeny virus. able blood obtained each four kidney allograft recipients long-term antirejection therapy, long not included in culture medium. In addition, we asked what pretreatment U-937 monocytic line primary monocytes/macrophages might have by HIV-1. no demonstrable either type.