The effect of polymorphisms in the promoter of the BIRC5 gene on the risk of oesophageal squamous cell carcinoma and patient's outcomes.

摘要: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) is an proteins and plays a key role in or programmed cell death. In the present study, we evaluated effect BIRC5 gene polymorphisms on risk developing oesophageal squamous carcinoma (ESCC) patients' outcomes high-incidence population from northern China. A population-based case-control study was performed 597 ESCC patients control subjects.Survival data were available for 211 who received platinum-based chemotherapy after surgery. Five (-31 C>G, -241 C>T, -625 G>C, -644 T>C -1547 A>G) promoter genotyped by polymerase chain reaction-ligase detection reaction (PCR-LDR) method. Compared with -31 CC genotype, CG/GG genotype C>G single nucleotide polymorphism (SNP) associated significant elevated [adjusted odds ratio (OR) = 1.40, 95% confidence interval (CI) 1.07-1.84]. Interestingly, this association stronger among females, younger non-smokers stratified analyses (adjusted OR 1.72, CI 1.07-2.75; adjusted 1.61, 1.10-2.36; 1.80, 1.26-2.58, respectively]. Survival showed that T allele C>T SNP poor prognosis [hazard (HR) 2.99, 1.09-8.19) C G>C good (HR 0.62, 0.38-0.99) patients. The may be involved development ESCC, useful prognostic markers ESCC.