PREDICTION OF THE TREAMENT RESPONSE TO AN ANTI-EGFR MOLECULE OF A SUBJECT SUFFERING OF RENAL CANCER
作者： Pages Gilles , Grepin Renaud
DOI:
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摘要: The present invention relates to the field of medicine and in particular treatment renal cancer prediction response a subject an anti-epidermal growth factor receptor (EGFR) molecule. More particularly, inventors herein describe single nucleotide polymorphism influencing anti-EGFR therapy methods distinguish sensitive from resistant and/or for providing with optimized personalized anti- EGFR therapy. It further products, including compositions kits, as well uses thereof context invention.
lens.org 参考文章(59)
Robert J. Motzer, Robert Amato, Mary Todd, Wen‐J Poo Hwu, Roger Cohen, Jose Baselga, Hyman Muss, Michael Cooper, Richard Yu, Michelle S. Ginsberg, Michael Needle, Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma. Investigational New Drugs. ,vol. 21, pp. 99- 101 ,(2003) , 10.1023/A:1022928612511
Yiru Xu, Li-Jun Tan, Vladimir Grachtchouk, John J. Voorhees, Gary J. Fisher, Receptor-type Protein-tyrosine Phosphatase-κ Regulates Epidermal Growth Factor Receptor Function * Journal of Biological Chemistry. ,vol. 280, pp. 42694- 42700 ,(2005) , 10.1074/JBC.M507722200
Katsura H. Nishi, Hirotaka Nishi, Alfred C. Johnson, Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia. Cancer Research. ,vol. 62, pp. 827- 834 ,(2002)
Beverly Drucker, Jennifer Bacik, Michelle Ginsberg, Stephanie Marion, Paul Russo, Madhu Mazumdar, Robert Motzer, Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma. Investigational New Drugs. ,vol. 21, pp. 341- 345 ,(2003) , 10.1023/A:1025472712456
Agata Szade, Anna Grochot-Przeczek, Urszula Florczyk, Alicja Jozkowicz, Jozef Dulak, Cellular and molecular mechanisms of inflammation-induced angiogenesis Iubmb Life. ,vol. 67, pp. 145- 159 ,(2015) , 10.1002/IUB.1358
Guru Sonpavde, Christopher D Willey, Sunil Sudarshan, Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma Expert Opinion on Investigational Drugs. ,vol. 23, pp. 305- 315 ,(2014) , 10.1517/13543784.2014.871259
Renaud Grépin, Damien Ambrosetti, Alexandre Marsaud, Lauris Gastaud, Jean Amiel, Florence Pedeutour, Gilles Pagès, The Relevance of Testing the Efficacy of Anti-Angiogenesis Treatments on Cells Derived from Primary Tumors: A New Method for the Personalized Treatment of Renal Cell Carcinoma PLoS ONE. ,vol. 9, pp. e89449- ,(2014) , 10.1371/JOURNAL.PONE.0089449
G Pages, R Grepin, M Guyot, M Jacquin, J Durivault, E Chamorey, A Sudaka, C Serdjebi, B Lacarelle, J-Y Scoazec, S Negrier, H Simonnet, Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab/Avastin treatment: the role of CXCL cytokines. Oncogene. ,vol. 31, pp. 1683- 1694 ,(2012) , 10.1038/ONC.2011.360
MªB. Garcia-Cenador, J.M. Lopez-Novoa, J. Diez, F.J. Garcia-Criado, Effects and mechanism of organ protection by cardiotrophin-1. Current Medicinal Chemistry. ,vol. 20, pp. 246- 256 ,(2012) , 10.2174/092986713804806702
Susumu Kobayashi, Titus J. Boggon, Tajhal Dayaram, Pasi A. Jänne, Olivier Kocher, Matthew Meyerson, Bruce E. Johnson, Michael J. Eck, Daniel G. Tenen, Balázs Halmos, EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib The New England Journal of Medicine. ,vol. 352, pp. 786- 792 ,(2005) , 10.1056/NEJMOA044238