Optical Mapping in hiPSC-CM and Zebrafish to Resolve Cardiac Arrhythmias
作者： Bert Vandendriessche , Ewa Sieliwonczyk , Maaike Alaerts , Bart L. Loeys , Dirk Snyders
关键词:
摘要: Inherited cardiac arrhythmias contribute substantially to sudden death in the young. The underlying pathophysiology remains incompletely understood because of lack representative study models and labour-intensive nature electrophysiological patch clamp experiments. Whereas is still considered gold standard for investigating electrical properties a cell, optical mapping voltage calcium transients has paved way high-throughput studies. Moreover, development human-induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) enabled patient specific cell lines capturing full genomic background. Nevertheless, hiPSC-CMs do not fully address complex interactions between various types heart. Studies using vivo models, are therefore necessary. Given analogies human zebrafish cardiovascular system, emerged as cost-efficient model arrhythmogenic diseases. In this review, we describe how hiPSC-CM employed primary disorders. We provide an overview contemporary phenotyping tools discuss more depth different strategies available mapping. consider current advantages disadvantages both tool propose further improvement. Overall, combination experimental readouts at cellular (hiPSC-CM) whole organ (zebrafish) level can raise our understanding complexity inherited arrhythmia disorders next level.
mdpi.com
sci-hub.st 参考文章(141)
Robert N. Wilkinson, Chris Jopling, Fredericus J.M. van Eeden, Zebrafish as a model of cardiac disease. Progress in Molecular Biology and Translational Science. ,vol. 124, pp. 65- 91 ,(2014) , 10.1016/B978-0-12-386930-2.00004-5
Matthew Betzenhauser, Geoffrey Pitt, Charles Antzelevitch, Calcium Channel Mutations in Cardiac Arrhythmia Syndromes Current Molecular Pharmacology. ,vol. 8, pp. 133- 142 ,(2015) , 10.2174/1874467208666150518114857
Rami Shinnawi, Irit Huber, Leonid Maizels, Naim Shaheen, Amira Gepstein, Gil Arbel, Anke J. Tijsen, Lior Gepstein, Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters Stem cell reports. ,vol. 5, pp. 582- 596 ,(2015) , 10.1016/J.STEMCR.2015.08.009
Kirsi Penttinen, Heikki Swan, Sari Vanninen, Jere Paavola, Annukka M. Lahtinen, Kimmo Kontula, Katriina Aalto-Setälä, Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models. PLOS ONE. ,vol. 10, pp. 0125366- ,(2015) , 10.1371/JOURNAL.PONE.0125366
Yongming Ren, Min Young Lee, Simon Schliffke, Jere Paavola, Peter J. Amos, Xin Ge, Mingyu Ye, Shenjun Zhu, Grant Senyei, Lawrence Lum, Barbara E. Ehrlich, Yibing Qyang, Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. Journal of Molecular and Cellular Cardiology. ,vol. 51, pp. 280- 287 ,(2011) , 10.1016/J.YJMCC.2011.04.012
Kerstin Howe, Matthew D Clark, Carlos F Torroja, James Torrance, Camille Berthelot, Matthieu Muffato, John E Collins, Sean Humphray, Karen McLaren, Lucy Matthews, Stuart McLaren, Ian Sealy, Mario Caccamo, Carol Churcher, Carol Scott, Jeffrey C Barrett, Romke Koch, Gerd-Jörg Rauch, Simon White, William Chow, Britt Kilian, Leonor T Quintais, José A Guerra-Assunção, Yi Zhou, Yong Gu, Jennifer Yen, Jan-Hinnerk Vogel, Tina Eyre, Seth Redmond, Ruby Banerjee, Jianxiang Chi, Beiyuan Fu, Elizabeth Langley, Sean F Maguire, Gavin K Laird, David Lloyd, Emma Kenyon, Sarah Donaldson, Harminder Sehra, Jeff Almeida-King, Jane Loveland, Stephen Trevanion, Matt Jones, Mike Quail, Dave Willey, Adrienne Hunt, John Burton, Sarah Sims, Kirsten McLay, Bob Plumb, Joy Davis, Chris Clee, Karen Oliver, Richard Clark, Clare Riddle, David Elliott, Glen Threadgold, Glenn Harden, Darren Ware, Sharmin Begum, Beverley Mortimore, Giselle Kerry, Paul Heath, Benjamin Phillimore, Alan Tracey, Nicole Corby, Matthew Dunn, Christopher Johnson, Jonathan Wood, Susan Clark, Sarah Pelan, Guy Griffiths, Michelle Smith, Rebecca Glithero, Philip Howden, Nicholas Barker, Christine Lloyd, Christopher Stevens, Joanna Harley, Karen Holt, Georgios Panagiotidis, Jamieson Lovell, Helen Beasley, Carl Henderson, Daria Gordon, Katherine Auger, Deborah Wright, Joanna Collins, Claire Raisen, Lauren Dyer, Kenric Leung, Lauren Robertson, Kirsty Ambridge, Daniel Leongamornlert, Sarah McGuire, Ruth Gilderthorp, Coline Griffiths, Deepa Manthravadi, Sarah Nichol, Gary Barker, Siobhan Whitehead, Michael Kay, Jacqueline Brown, Clare Murnane, Emma Gray, Matthew Humphries, Neil Sycamore, Darren Barker, David Saunders, Justene Wallis, Anne Babbage, Sian Hammond, Maryam Mashreghi-Mohammadi, Lucy Barr, Sancha Martin, Paul Wray, Andrew Ellington, Nicholas Matthews, Matthew Ellwood, Rebecca Woodmansey, Graham Clark, James D Cooper, Anthony Tromans, Darren Grafham, Carl Skuce, Richard Pandian, Robert Andrews, Elliot Harrison, Andrew Kimberley, Jane Garnett, Nigel Fosker, Rebekah Hall, Patrick Garner, Daniel Kelly, Christine Bird, Sophie Palmer, Ines Gehring, Andrea Berger, Christopher M Dooley, Zübeyde Ersan-Ürün, Cigdem Eser, Horst Geiger, Maria Geisler, Lena Karotki, Anette Kirn, Judith Konantz, Martina Konantz, Martina Oberländer, Silke Rudolph-Geiger, Mathias Teucke, None, The zebrafish reference genome sequence and its relationship to the human genome. Nature. ,vol. 496, pp. 498- 503 ,(2013) , 10.1038/NATURE12111
Arie O. Verkerk, Carol Ann Remme, Zebrafish: a novel research tool for cardiac (patho)electrophysiology and ion channel disorders. Frontiers in Physiology. ,vol. 3, pp. 255- 255 ,(2012) , 10.3389/FPHYS.2012.00255
Graham J. Lieschke, Peter D. Currie, Animal models of human disease: zebrafish swim into view Nature Reviews Genetics. ,vol. 8, pp. 353- 367 ,(2007) , 10.1038/NRG2091
David Hassel, Eberhard P. Scholz, Nicole Trano, Oliver Friedrich, Steffen Just, Benjamin Meder, Daniel L. Weiss, Edgar Zitron, Sabine Marquart, Britta Vogel, Christoph A. Karle, Gunnar Seemann, Mark C. Fishman, Hugo A. Katus, Wolfgang Rottbauer, Deficient Zebrafish Ether-à-Go-Go–Related Gene Channel Gating Causes Short-QT Syndrome in Zebrafish Reggae Mutants Circulation. ,vol. 117, pp. 866- 875 ,(2008) , 10.1161/CIRCULATIONAHA.107.752220
Chuanchau Jou, Kenneth Spitzer, Martin Tristani-Firouzi, Blebbistatin effectively uncouples the excitation-contraction process in zebrafish embryonic heart. Cellular Physiology and Biochemistry. ,vol. 25, pp. 419- 424 ,(2010) , 10.1159/000303046