Expression of serum- and glucocorticoid-regulated kinase 1 and its association with clinicopathological factors and the survival of patients with adenocarcinoma of the esophagogastric junction.

摘要: While the aberrant expression and controversial results of serum- glucocorticoid-regulated kinase (SGK1) have been reported in a number malignancies, SGK1 its possible association with progression adenocarcinoma esophagogastric junction (AEG) remain to be elucidated. To best our knowledge, localization was examined for first time present study cancerous adjacent tissue from 60 patients AEG, compared 20 healthy mucosa control samples. Furthermore, between clinicopathological characteristics, prognosis AEG statistically analyzed. The level identified significantly higher (P<0.0001) samples (65%) that (31.7%) (10%) Enhanced primarily localized cytoplasm associated differentiation (P=0.045) lymph node metastasis (P=0.006) AEG. Notably, increased demonstrated correlated poor overall survival (P=0.027). revealed profile is an indicator Thus, may potential molecular marker diagnosis, interference therapy