Expression of Lysyl Oxidase Predictive of Distant Metastasis of Laryngeal Cancer.
作者： Yoon Se Lee , Yangsoon Park , Minsu Kwon , Jong-Lyel Roh , Seung-Ho Choi
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摘要: ObjectiveTo investigate the prognostic significance of lysyl oxidase (LOX) expression in laryngeal cancer.Study DesignRetrospective chart review and histologic analysis.SettingTertiary referral academic center.Subjects MethodsPatients (N = 100) underwent surgical treatment for cancer had tissue specimens available. Immunohistochemical staining LOX was performed on microarrays, proportion intensity were evaluated. Patients with scores ≤6 classified into low group, while those >6 high group. We analyzed correlation between clinical factors as well prognosis.ResultsLOX predominantly expressed cytoplasm nuclei tumor cells. Kaplan-Meier analysis revealed that group worse overall survival recurrence-free rates than (P < .05). exhibited marginally significant lymph...
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