Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats.
作者： P Y Chen , P W Sanders
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摘要: Nitric oxide is a potent endogenous vasodilator that regulates arterial tone. A family of nitric synthases uses L-arginine and L-homoarginine stereospecifically as substrates for production in vivo. By preventing expression inducible but not constitutive synthases, glucocorticoids differentiate which enzyme this the predominant source generation given situation. We proposed defective produces salt-sensitive hypertension Dahl/Rapp rat. Plasma concentrations L-arginine, citrulline, ornithine (SS/Jr) salt-resistant (SR/Jr) rats on 8% sodium chloride chow 1 week did differ. However, intravenous infusion L-homoarginine, D-arginine, increased urinary excretion nitrate, degradation product oxide, simultaneously lowered blood pressure hypertensive SS/Jr rats. Oral also prevented development cyclic GMP nitrate these Dexamethasone, dose hypotension from parenteral injection lipopolysaccharide, completely increase resulted despite concomitant treatment with L-arginine. These studies supported an important role dexamethasone-suppressible synthesis prevention
sci-hub.se 参考文章(35)
Sanders Pw, Kirk Ka, Chen Py, St John Pl, Abrahamson Dr, Hypertensive nephrosclerosis in the Dahl/Rapp rat. Initial sites of injury and effect of dietary L-arginine supplementation. Laboratory Investigation. ,vol. 68, pp. 174- 184 ,(1993)
C.R. Lyons, G.J. Orloff, J.M. Cunningham, Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. Journal of Biological Chemistry. ,vol. 267, pp. 6370- 6374 ,(1992) , 10.1016/S0021-9258(18)42704-4
R M Palmer, S Moncada, E A Higgs, NITRIC OXIDE: PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY Pharmacological Reviews. ,vol. 43, pp. 109- 142 ,(1991)
Mark Salter, Richard G. Knowles, Salvador Moncada, Widespread tissue distribution, species distribution and changes in activity of Ca2+
-dependent and Ca2+
-independent nitric oxide synthases FEBS Letters. ,vol. 291, pp. 145- 149 ,(1991) , 10.1016/0014-5793(91)81123-P
Michael A. Marletta, Poksyn S. Yoon, Radha Iyengar, Cynthia D. Leaf, John S. Wishnok, Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry. ,vol. 27, pp. 8706- 8711 ,(1988) , 10.1021/BI00424A003
I. Sakuma, D. J. Stuehr, S. S. Gross, C. Nathan, R. Levi, Identification of arginine as a precursor of endothelium-derived relaxing factor Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 8664- 8667 ,(1988) , 10.1073/PNAS.85.22.8664
Giancarlo Tonolo, Robert Fraser, John M.C. Connell, Christopher J. Kenyon, Chronic low-dose infusions of dexamethasone in rats: effects on blood pressure, body weight and plasma atrial natriuretic peptide. Journal of Hypertension. ,vol. 6, pp. 25- 31 ,(1988) , 10.1097/00004872-198801000-00005
S. Moncada, D. D. Rees, R. Schulz, R. M. Palmer, Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 2166- 2170 ,(1991) , 10.1073/PNAS.88.6.2166
Paul W Sanders, Guillermo A Herrera, John H Galla, Robert L Lott, None, Human Bence Jones protein toxicity in rat proximal tubule epithelium in vivo. Kidney International. ,vol. 32, pp. 851- 861 ,(1987) , 10.1038/KI.1987.286
R. M. J. Palmer, A. G. Ferrige, S. Moncada, Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature. ,vol. 327, pp. 524- 526 ,(1987) , 10.1038/327524A0