The Role of TRP Channels and PMCA in Brain Disorders: Intracellular Calcium and pH Homeostasis.

摘要: Brain disorders include neurodegenerative diseases (NDs) with different conditions that primarily affect the neurons and glia in brain. However, risk factors pathophysiological mechanisms of NDs have not been fully elucidated. Homeostasis intracellular Ca2+ concentration pH (pHi) is crucial for cell function. The regulatory processes these ionic may be absent or excessive pathological conditions, leading to a loss death distinct regions ND patients. Herein, we review potential involvement transient receptor (TRP) channels NDs, where disrupted homeostasis leads death. capability TRP restore excite through regulation depending on level plasma membrane ATPase (PMCA) activity discussed detail. As PMCA simultaneously affects as well pHi, thus play vital roles modulating various types specific brain are expressed. For this reason, dysfunction and/or under disrupts neuronal due abnormal levels brain, resulting NDs. This addresses function controlling pH, which provide novel targets treating