Bone marrow T cells. I. Response to the T cell mitogens, phytohemagglutinin and concanavalin A.

摘要: Mouse bone marrow (BM) contains cells capable of responding in vitro to the T cell mitogens, phytohemagglutinin (PHA) and concanavalin A (Con A). These responses are less vigorous than those spleen cells. The optimal mitogen concentrations for BM different from cells; require twice as much PHA Con A. In terms relative these mean PHA/Con ratio adult is reversed compared with spleen; it 0.42 whereas 1.3. This dichotomy even clearer newborn (6- 8-day-old) mice. Newborn respond poorly relatively well On contrary, almost do but they not findings suggest a significant difference between which mitogens.