Chapter 7. Vascular Proliferative Disease

摘要: Publisher Summary The most common initial form of vascular proliferative disease is atherosclerosis, a occlusive event that occurs over the course many years or decades as consequence abnormal cholesterol deposition in vessel walls. normal primary function blood vessels to carry nutrients and oxygen capillary beds metabolic products carbon dioxide for removal from body. Natural defense systems have evolved insure control these functions. These include platelet adhesion at luminal surface injured walls induce formation thrombi lead clot prevention bleeding into extravascular space. In case extensive insults wall, inflammatory cells also accumulate aid repair. Under certain conditions, protective mechanisms are overstimulated cause diseases; being atherosclerosis. treatments diseases numerous diverse, including percutaneous transluminal coronary angioplasty (PTCA balloon angioplasty), bypass interpositional grafting, carotid endarterectomy, hemodialysis access grafts, transplant, stents. Treatments, while initially often successful, secondary narrowing called restenosis. Reduction disease, such restenosis, very complex challenge related heterogeneous expression this disease. While sharing features occlusion, typically result smooth muscle (SMC) proliferation matrix encroach on lumen, restenotic initiated by wide variety stimuli. Further, stimuli occur redundant but distinct processes.