Design of liposomes for enhanced local release of drugs by hyperthermia
作者： M. Yatvin , J. Weinstein , W. Dennis , R Blumenthal
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摘要: Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis Escherichia coli is inhibited and killing of the cells enhanced heating neomycin-containing liposomes their phase transition temperature maximize release. presence serum ratio 44 degrees C that 37 made greater than 100:1, suggesting possible applications treatment tumors or infection.
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