Prognostic value of long non-coding RNA HOTAIR in various cancers.

摘要: Long non-coding RNA has been involved in cancer progression, and high HOX transcript antisense intergenic (HOTAIR) is thought to be a poor prognostic indicator tumorigenesis of multiple types cancer. Hence, the present study further reveals its value tumor malignancy. A systematic review PubMed Web Science was carried out select literatures relevant correlation between HOTAIR expression levels clinical outcome various tumors. Overall survival (OS), metastasis-free (MFS), recurrence-free (RFS), disease-free (DFS) were subsequently analyzed. Data from studies directly reporting hazard ratio (HR) corresponding 95% confidence interval (CI) or P as well curves pooled current meta-analysis. total 2255 patients 19 almost published 2011 later included analysis. The results suggest that highly associated with HR for OS 2.33 (95%CI = 1.77-3.09, Pheterogeneity 0.016). Stratified analyses indicate elevated appears powerful biomarker colorectal (HR 3.02, 95CI% 1.84-4.95, 0.699) esophageal squamous cell carcinomas 2.24, 1.67-3.01, 0.711), similar effect also observed analysis method specimen, except ethnicity. In addition, Hazard ratios up-regulation MFS, RFS, DFS 2.32 (P<0.001), 1.98 (P 0.369), 3.29 0.001), respectively. summary, level intimately an adverse numerous cancers, suggesting may act potential development malignancies.