Combined spinal-epidural analgesia vs. intermittent bolus epidural analgesia for pain relief after major abdominal surgery. A prospective, randomised, double-blind clinical trial.
作者： D. M. Stamenkovic , V. Geric , Z. Slavkovic , J. Raskovic , M. Djordjevic
DOI: 10.1111/J.1742-1241.2007.01642.X
关键词:
摘要: Summary Background: The primary aim of this study was to compare the efficacy combined spinal-epidural (CSE) analgesia vs. intermittent bolus epidural (EA) for pain relief after major abdominal surgery. secondary assess effects fentanyl addition subarachnoid morphine and bupivacaine. Methods: This a prospective, randomised, double-blind trial; 160 patients scheduled surgery enrolled. All had thoracic catheter administration intra-operative postoperative analgesia. Patients were assigned one four groups: (i) morphine, bupivacaine (MBF group); (ii) (MB (iii) (M group) (iv) normal saline (EA group). Use additional intravenous (i.v.) recorded measure need supplemental Pain at rest, with movement, cough (measured visual analogue scale), requests, side over 72 h postoperatively. Results: Compared EA group, MBF group significantly reduced lower requirements during first 24 h (p < 0.001) discontinuation (p = 0.041). required less compared all other groups (p < 0.001), i.v. M (p < 0.001). Conclusions: Combined improved in immediate period. decreased
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