The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis.
作者： Qing-Shan Ji , Bing Qi , Yue-Chun Wen , Lian Liu , Xiao-Ling Guo
DOI: 10.3980/J.ISSN.2222-3959.2015.01.27
关键词:
摘要: Aim To investigate the association of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG). Methods Published manuscripts from PubMed and EMBASE were identified until May 2014. Summary odds ratios (ORs) 95% confidence intervals (CIs) for LOXL1 (rs1048661, rs2165241 rs3825942) risk XFS/XFG estimated using random- or fixed- effect model. Results The three rs3825942, rs2165241) associated an increased among Caucasians, OR 2.19(1.96-2.45), 8.8 (6.05-12.79) 3.41 (3.11-3.73), respectively. On contrast, rs1048661 rs2165241, but not rs3825942 polymorphism, have a potential protective on in Asians, 0.06 (0.02-0.18), 0.15 (0.09-0.25), Conclusion There is strong evidence that are risk. strength might be ethnicity-dependent.
ijo.cn参考文章(41)
Christiane Wolf, Eugen Gramer, Bertram Müller-Myhsok, Francesca Pasutto, Gwendolyn Gramer, Bernd Wissinger, Nicole Weisschuh, Lysyl oxidase-like 1 gene polymorphisms in German patients with normal tension glaucoma, pigmentary glaucoma and exfoliation glaucoma. Journal of Glaucoma. ,vol. 19, pp. 136- 141 ,(2010) , 10.1097/IJG.0B013E31819F9330
Gottfried OH Naumann, Ursula Schlötzer-Schrehardt, Michael Küchle, Pseudoexfoliation syndrome for the comprehensive ophthalmologist: Intraocular and systemic manifestations Ophthalmology. ,vol. 105, pp. 951- 968 ,(1998) , 10.1016/S0161-6420(98)96020-1
Do Young Park, Changwon Kee, Hong-Hee Won, Hyun-Kyung Cho, Evaluation of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome in a Korean population. Molecular Vision. ,vol. 19, pp. 448- 453 ,(2013)
Katalin Csiszar, Lysyl oxidases: a novel multifunctional amine oxidase family. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 70, pp. 1- 32 ,(2001) , 10.1016/S0079-6603(01)70012-8
Fumihiko Mabuchi, Shigeo Tsukahara, Yoichi Sakurada, Hiroyuki Iijima, Zentaro Yamagata, Kenji Kashiwagi, Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome Molecular Vision. ,vol. 14, pp. 1303- 1308 ,(2008)
Jeffrey Liebmann, Robert Ritch, Mansoor Sarfarazi, Ahti Tarkkanen, Jose A. Aragon-Martin, Anne H. Child, Colm O’Brien, Tayebeh Rezaie, Caroline J. Cobb, Anthony Spiteri, Franco Mercieca, Karima Blaaow, Karim F. Damji, Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma. Molecular Vision. ,vol. 14, pp. 533- 541 ,(2008)
Govindasamy Kumaramanickavel, Vedam Lakshmi Ramprasad, Nagasamy Soumittra, Lingam Vijaya, Ronnie George, Ferdinamarie Sharmila, Association of non-synonymous single nucleotide polymorphisms in the LOXL1 gene with pseudoexfoliation syndrome in India Molecular Vision. ,vol. 14, pp. 318- 322 ,(2008)
K. Kenyon, W.S. Modi, S. Contente, R.M. Friedman, A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25. Journal of Biological Chemistry. ,vol. 268, pp. 18435- 18437 ,(1993) , 10.1016/S0021-9258(17)46643-9
R. Rand Allingham, Benjamin T. Whigham, Michael A. Hauser, Yutao Liu, Xuejun Qin, Michele Ramsay, Trevor R. Carmichael, Silke Schmidt, Susan E.I. Williams, Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population Molecular Vision. ,vol. 16, pp. 705- 712 ,(2010)
Ningli Wang, Wenru Liu, Ling Chen, Hongyan Jia, Wotan Zeng, Liyun Jia, Ningpu Liu, Hailin Meng, Guangxian Tang, Sujie Fan, Huaizhou Wang, Chun Zhang, Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population Molecular Vision. ,vol. 15, pp. 2349- 2357 ,(2009)