Chondrons from articular cartilage. III. Morphologic changes in the cellular microenvironment of chondrons isolated from osteoarthritic cartilage.
作者： C. Anthony Poole , Akira Matsuoka , Jennifer R. Schofield
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摘要: Chondrons were isolated from human and canine osteoarthritic cartilage using low-speed homogenization techniques. Changes in chondron morphology evaluated differential interference-contrast microscopy, phase-contrast histochemical ultrastructural methods. Chondrocyte viability was assessed fluorescein diacetate staining, metabolism investigated autoradiography. The results suggest that initial changes the collagen proteoglycan distribution within are followed by chondrocyte proliferation to form clusters. These techniques offer potential study cell matrix interactions degenerative osteoarthritis.
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