Poly (I:C) enhances the anti-tumor activity of canine parvovirus NS1 protein by inducing a potent anti-tumor immune response
作者： Shishir Kumar Gupta , Pavan Kumar Yadav , A. K. Tiwari , Ravi Kumar Gandham , A. P. Sahoo
DOI: 10.1007/S13277-016-5093-Z
关键词:
摘要: The canine parvovirus NS1 (CPV2.NS1) protein selectively induces apoptosis in the malignant cells. However, for an effective vivo tumor treatment strategy, oncolytic agent also needs to induce a potent anti-tumor immune response. In present study, we used poly (I:C), TLR3 ligand, as adjuvant along with CPV2.NS1 find out if combination can enhance activity by inducing 4T1 mammary carcinoma cells were Balb/c mice. results suggested that when given CPV2.NS1, not only significantly reduced growth but augmented response against antigen(s) indicated increase blood CD4+ and CD8+ counts infiltration of tissue. Further, serum analysis cytokines revealed Th1 (IFN-γ IL-2) upregulated group indicating activation cell-mediated study reports efficacy (I:C) inhibiting generating active without any visible toxicity. our may help developing (I: C) cancer therapeutic regime treat various malignancies.
springer.com
sci-hub.se 参考文章(76)
Jürg P. F. Nüesch, Jean Rommelaere, Tumor suppressing properties of rodent parvovirus NS1 proteins and their derivatives. Advances in Experimental Medicine and Biology. ,vol. 818, pp. 99- 124 ,(2014) , 10.1007/978-1-4471-6458-6_5
Parvin Forghani, Edmund K. Waller, Poly (I: C) modulates the immunosuppressive activity of myeloid-derived suppressor cells in a murine model of breast cancer. Breast Cancer Research and Treatment. ,vol. 153, pp. 21- 30 ,(2015) , 10.1007/S10549-015-3508-Y
W. RUF, J. DISSE, T. C. CARNEIRO-LOBO, N. YOKOTA, F. SCHAFFNER, Tissue Factor and Cell Signalling in Cancer Progression and Thrombosis Journal of Thrombosis and Haemostasis. ,vol. 9, pp. 306- 315 ,(2011) , 10.1111/J.1538-7836.2011.04318.X
Yuan Yuan Wang, Jiong Liu, Qing Zheng, Zhi Hua Ran, Nathalie Salomé, Michèle Vogel, Jean Rommelaere, Shu Dong Xiao, Zheng Wang, None, Effect of the parvovirus H-1 non-structural protein NS1 on the tumorigenicity of human gastric cancer cells. Journal of Digestive Diseases. ,vol. 13, pp. 366- 373 ,(2012) , 10.1111/J.1751-2980.2012.00601.X
Kerstin N. Schmidt, Beatrice Leung, Mandy Kwong, Kol A. Zarember, Sanjeev Satyal, Tony A. Navas, Fay Wang, Paul J. Godowski, APC-Independent Activation of NK Cells by the Toll-Like Receptor 3 Agonist Double-Stranded RNA The Journal of Immunology. ,vol. 172, pp. 138- 143 ,(2004) , 10.4049/JIMMUNOL.172.1.138
Shizuo Akira, Kiyoshi Takeda, Tsuneyasu Kaisho, Toll-like receptors: critical proteins linking innate and acquired immunity Nature Immunology. ,vol. 2, pp. 675- 680 ,(2001) , 10.1038/90609
Andrew J. Currie, Robbert G. van der Most, Steve A. Broomfield, Amy C. Prosser, Michael G. Tovey, Bruce W. S. Robinson, Targeting the Effector Site with IFN-αβ-Inducing TLR Ligands Reactivates Tumor-Resident CD8 T Cell Responses to Eradicate Established Solid Tumors Journal of Immunology. ,vol. 180, pp. 1535- 1544 ,(2008) , 10.4049/JIMMUNOL.180.3.1535
Ravikumar Muthuswamy, Liwen Wang, Jamie Pitteroff, Jeffrey R Gingrich, Pawel Kalinski, Combination of IFNα and poly-I:C reprograms bladder cancer microenvironment for enhanced CTL attraction Journal for ImmunoTherapy of Cancer. ,vol. 3, pp. 6- 6 ,(2015) , 10.1186/S40425-015-0050-8
Brian D. Poole, Yuory V. Karetnyi, Stanley J. Naides, Parvovirus B19-Induced Apoptosis of Hepatocytes Journal of Virology. ,vol. 78, pp. 7775- 7783 ,(2004) , 10.1128/JVI.78.14.7775-7783.2004
Darin A. Wick, Spencer D. Martin, Brad H. Nelson, John R. Webb, Profound CD8+ T cell immunity elicited by sequential daily immunization with exogenous antigen plus the TLR3 agonist poly(I:C). Vaccine. ,vol. 29, pp. 984- 993 ,(2011) , 10.1016/J.VACCINE.2010.11.036