The search and destroy strategy prevents spread and long-term carriage of methicillin-resistant Staphylococcus aureus: results from the follow-up screening of a large ST22 (E-MRSA 15) outbreak in Denmark.

摘要: In the aftermath of a methicillin-resistant Staphylococcus aureus (MRSA) ST22 hospital outbreak, we investigated prevalence long-term carriage, efficacy MRSA decolonization treatment (DT) and spread to households patients healthcare workers (HCWs). Furthermore, evaluated repeated DT in carriers. Of 250 index persons (58 HCWs 192 patients), 102 (19 83 patients) 67 household members agreed participate. Samples from all 169 were taken nose, throat, wounds devices/catheters, urine samples additionally persons. companion animals (n = 35) nostrils anus. Environmental sites 490) screened telephone, television remote control, toilet flush handle, favourite chair skirting board beside bed. Sixteen (19%) two members, but no HCWs, ST22-positive. The throat was most frequent site colonization. multivariate analysis, chronic disease (p <0.001) pharyngeal carriage associated with carriage. found environments four All tested negative. MRSA-positive decolonized using nasal mupirocin TID daily chlorhexidine body hair wash for 5 days. Pharyngeal carriers also received fucidic acid (500 mg TID) combined rifampicin (600 BID) or clindamycin 7 home environment cleaned on days 2 5. At end follow-up, ten 16 contacts MRSA-negative. conclusion, is possible, should include environment.