REGIV as a potential biomarker for peritoneal dissemination in gastric adenocarcinoma

摘要: Background This study examined the clinical significance of regenerating islet-derived family member 4 (REGIV) in surgically resected gastric tumors. The potential REGIV as a biomarker cancer was also assessed including its predictive value for prognosis and recurrence after surgery. Methods Immunohistochemistry performed to assess expression status specimens. quantitative genetic diagnostic method, transcription-reverse transcription concerted reaction (TRC) that targeted mRNA applied prediction peritoneal cancer. Results Positive immunostaining observed 85 cases (52.5%), correlated significantly with diffuse type histopathology (P = 0.001), advanced T stage (P = 0.022), frequent (P = 0.009). Multivariate analysis identified (P < 0.001) (P = 0.034) independent prognostic factors recurrence-free survival. Overexpression protein evident majority tumors (93.8%). by TRC could be marker curative operation. Conclusions REGIV overexpression is common primary potentially suitable dissemination. mRNA, resection. J. Surg. Oncol. 2012; 105:189–194. © 2011 Wiley Periodicals, Inc.