Safety, bioavailability and mechanism of action of nitric oxide to control Bovine Respiratory Disease Complex in calves entering a feedlot
作者： G. Regev-Shoshani , S. Vimalanathan , D. Prema , J.S. Church , M.W. Reudink
DOI: 10.1016/J.RVSC.2013.12.012
关键词:
摘要: Abstract Bovine Respiratory Disease Complex (BRDc), a multi-factorial disease, negatively impacts the cattle industry. Nitric oxide (NO), naturally occurring molecule, may have utility controlling incidence of BRDc. Safety, bioavailability, toxicology and tolerance/stress administering NO to is evaluated herein. Thirteen, crossbred, multiple-sourced, commingled commercial weaned beef calves were treated multiple times intranasally over 4 week period with either nitric releasing solution (treatment) or saline (control). Exhaled NO, methemoglobin percent (MetHg) serum nitrites demonstrated biological availability as result treatment. Cortisol levels, tissue nitrites, behavior gross macroscopic pathology organs all normal. Moreover, preliminary in vitro studies using Mannheimia haemolytica, Infectious Rhinotracheitis, Parainfluenza-3 Syncytial Virus, suggest potential explanation for previously efficacy These data confirm safety lack residual treatment cattle, along bactericidal virucidal effects.
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