Lessons from the Genome-Wide Association Studies for Complex Multifactorial Disorders and Traits
作者： Jacques S. Beckmann , Stylianos E. Antonarakis
DOI: 10.1007/978-3-540-37654-5_10
关键词:
摘要: Genome-wide association studies (GWAS) between common sequence variation and phenotypic were recently performed for a large number of human phenotypes. This was possible due to the discovery in populations, development technologies large-scale inexpensive genotyping, collection very well-phenotyped samples. GWAS successful identifying low risk alleles candidate genes or loci. More importantly, these disclosed unexpected molecular pathways different common, multifactorial disorders traits, thereby providing new working hypotheses. Yet, current clinical utility findings remains limited.
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