Glycoconjugation using saccharyl fragments
作者： Shawn Defrees
DOI:
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摘要: The present invention provides conjugates between a substrate, e.g., peptide, glycopeptide, lipid, etc., and modified saccharyl fragment bearing modifying group such as water-soluble polymer, therapeutic moiety or biomolecule. are linked via the enzymatic conversion of activated into glycosyl linking that is interposed covalently attached to substrate group. formed from substrates by action sugar transferring enzyme, glycosyltransferase. For example, when enzyme onto either an amino acid residue peptide. Also provided pharmaceutical fonnulations include conjugates. Methods for preparing also within scope invention.
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